Academic background&position
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Major papers
1. [SCIE] Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection [Microbiome] - 2023-11-23
2. [SCIE] PET Imaging of System xC - in Immune Cells for Assessment of Disease Activity in Mice and Patients with Inflammatory Bowel Disease [JOURNAL OF NUCLEAR MEDICINE] - 2022-10-01
3. [SCIE]
LKB1 in Intestinal Epithelial Cells Regulates Bile Acid Metabolism by Modulating FGF15/19 Production
[CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY] - 2022-01-01
4. [SCIE]
A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon
[CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY] - 2022-01-01
5. [SCIE] Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor plus niche cells [EXPERIMENTAL AND MOLECULAR MEDICINE] - 2021-09-09
Offices
Mucosal Immunology Lab
The human gut is
populated with as many as 100 trillion (1014) cells, including
bacteria, fungi, viruses, and other microbial and eukaryotic species.
These complex, heavily diverse communities provide tremendous enzymatic
capability and thus play a fundamental role in manipulating host physiology.
It is well established that five bacterial phyla, Firmicutes, Bacteroidetes,
Actinobacteria, Proteobacteria, and Verrucomicrobia,
are dominant components of the human gut microbiota.
More than 90% of the bacterial populations are gram-negative anaerobes and include
the predominant genera Bacteroides, Eubacterium, Bifidobacterium, and Fusobacterium.
Additionally, the gut microbiota is indispensable for carbohydrate
fermentation and nutrient absorption,
protection of pathogenic bacteria
and regulation of metabolic disorders.
The
host intestine is unique with respect to its constant exposure to a plethora of
antigens from daily food intake and exogenous bacteria. The resident gut
microbiota contains a number of components able to activate both innate and
adaptive immunity responses.
For example, the majority of intestinal bacteria are gram-negative anaerobes equipped
with diverse agents, such as lipopolysaccharide
(LPS) and flagella, allowing for innate signaling to intestinal epithelial
cells through toll-like receptors (TLRs).
Segmented filamentous bacteria (SFB) embedded in the ileum can also stimulate
adaptive, T helper 17 (TH17) responses and induce the production of
mucosal immunoglobulin A (IgA).
In addition, commensal microbe-derived butyrate is associated with regulatory T
(Treg) cell differentiation in the colon. Our lab members are working for discovery underlying mechanism how mucosal immunity and diseases controlled by gut commensal microbes.
Faculty/Research
