Academic background&position

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Major papers

1. [SCIE] Autotaxin inhibition attenuates the aortic valve calcifcation by suppressing infammation-driven fbro-calcifc remodeling of valvular interstitial cells [BMC Medicine] - 2024-03-14
2. [SCIE] Concomitant induction of SLIT3 and microRNA?218?2 in macrophages by toll?like receptor 4 activation limits osteoclast commitment [Cell Communication and Signaling] - 2023-08-18
3. [SCIE] Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity [Cell and Bioscience] - 2023-03-07
4. [SCIE] Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways [International Journal of Oral Science] - 2022-04-22
5. [SCIE] Characterization of Circulating IL-7R Positive Cell Populations for Early Detection of Pancreatic Ductal Adenocarcinoma [JOURNAL OF CLINICAL MEDICINE] - 2021-09-15

Patents

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Offices

Bone-associated immune cell biology lab (Biomedical Science)

 

Our research lab, Chang's Osteoimmunology Lab (CLOI) belongs to the medical science class of Ulsan Medical School. Currently, a number of studies have been conducted with grants from the Korea Research Foundation, the Ministry of Health and Welfare, the Asan Life Sciences Institute, and the Center for Basic Medicine MRC.

This laboratory focuses on the study of inflammation-related diseases (inflammatory bone disease, metabolic diseases related to calcification, and bone cancer) with the doctoral research team and additional researchers.

In particular, we participate in the MRC stem cell immunomodulation research center selected in 2018 to conduct research on development of therapeutic target cell therapy for intractable immune-mediated diseases by exploring by exploring immune-control targets based on the research of stem cells and the immune-activation control interaction system. To that end, we are conducting research on cell levels, disease and animal models and clinical usability verification.

In this lab, we conduct major industry-academic cooperation tasks using disease animal models.
1. Analysis of disease conditions using bone disease animal model and in vitro research at cell level
2. Functional analysis of target materials using inflammatory cardiovascular disease animal model
3. Functional analysis and cellular mechanism of target substances using the bone-metastatic cancer animal model
4. Functional study of therapeutic targets using the inflammatory metabolic diseases model
5. Research on the development of cellular therapy for the treatment of incurable immune diseases through the development of stem cells and immune control targets

Publications

1. Osteoclast-secreted SLIT3 coordinates bone resorption and formation. J. Clin. Invest., 2018 March 5.

2. Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulinlike Growth Factor-1 Signaling in Valvular Interstitial Cells. Circulation. 2017 Feb.

3. Interleukin-32 Gamma Stimulates Bone Formation by Increasing miR-29a in Osteoblastic Cells and Prevents the Development of Osteoporosis. Sci Rep. 2017 Jan.

4. Upregulation of brain-derived neurotrophic factor in advanced gastric cancer contributes to bone metastatic osteolysis by inducing long pentraxin 3. Oncotarget. 2016 Jul.

5. Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes. Sci Rep. 2016 Jan.

6. High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation. Arthritis Res Ther. 2015 Dec.

7. Pentraxin-3 Silencing Suppresses Gastric Cancer-related Inflammation by Inhibiting Chemotactic Migration of Macrophages. Anticancer Res. 2015 May.

8. Atrazine induces endoplasmic reticulum stress-mediated apoptosis of T lymphocytes via the caspase-8-dependent pathway. Environ Toxicol. 2016 Aug.

9. Beclin-1 Is Required for RANKL-Induced Osteoclast Differentiation. J Cell Physiol. 2014 Dec.

10. PTX3 Stimulates Osteoclastogenesis by Increasing Osteoblast RANKL Production. J Cell Physiol. 2014 Nov.