연구실 소개
염증면역학 (LII: Lab of Inflammation and Immunity)
연구주제
급,만성 염증
연관질환 (예, 섬유화질환,
암, 패혈증, 자가면역, 노화, 뇌질환 등)을
제어하는 조직항상성인자 발굴 및 작용기전 탐색, 이를 이용한 치료방법을 연구함.
i)야생형
또는 유전자변형 마우스에 다양한 질환을 유도시킨 후, ii) 면역세포 이동, 면역세포와 다양한 세포 (혈관내피세포, 상피세포, 섬유아세포, 신경세포, 희소돌기아교세포 등)들간의 상호작용 결과를 분석함. iii) 분자, 세포, 조직, 및 개체수준에서 병태생리학적 특성을 비교함으로써, iv) 조직항상성인자
후보군의 질환연관성을 규명하고, v) 환자시료에서 이를 검증, vi)
조직항상성 인자를 제어하는 단백질 또는 바이러스를 도입, 마우스에서의 치료효과를 시험함.
실험실 사람들
이승환 (2012.02
- 2018.06): 박사과정/박사후연구원 (go to
University of Pennsylvania, July 2018)
김동영 (2013.09
- 현재): 박사과정
임다해 (2017.10
- 현재): 박사후연구원
유현진 (2018.02
- 현재): volunteer
최유진 (2018.03
- 현재): volunteer
졸업생 및 이전 연구원
Yan Fu (2015-2017:
석사과정)
Feifeng Jing
(2014-2016: 박사과정수료)
강윤영
(2012-2014: 석사과정)
장정인
(2012-2014: 석사과정수료)
조금실 (2011: 석사후연구원)
김혜순 (2010-2013:
조교)
발표논문 (2010 연구실 이후)
Fu Y, Tsauo J,
Sun Y, Wang Z, Kim KY, Lee SH, Kim DY, Jing F, Lim D, Song HY, Hyun H, Choi EY. (corresponding author)
Developmental
endothelial locus-1 prevents development of peritoneal adhesions in mice.
Biochem Biophys Res Commun. 2018 Apr 20.
Lee S, Lim W, jo
D, Jung JS, Kim S, Jo G, Min JJ, Choi EY#, Hyun H#.(co-corresponding
author)
Near-infrared
fluorescent sorbitol probe for tumor diagnosis in vivo
J Experimental
and Engineering Chemistry, in press
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Lee CH, Choi
EY. (corresponding author)
Macrophages and
inflammation
J Rheum Dis
2018;25(1):11-18
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Oh SH, Kim JW,
Kim Y, Lee MN, Kook MS, Choi
EY, Im SY, Koh JT.
The extracellular matrix
protein Edil3 stimulates osteoblast differentiation through the integrin
α5β1/ERK/Runx2 pathway.
PLoS One. 2017
Nov 28;12(11):e0188749.
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Jing F., Choi E.Y. (corresponding author)
Potential of cells and cytokine/chemokine to
regulate tertiary lymphoid structures in human diseases.
Immune Network 2016 Oct; 16(5):271-280
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Lee H.S., Choi E.J., Lee K.S., Kim H.R., Na B.R., Kwon M.S., Jeong G.S., Choi H.G., Choi E.Y.#,
Jun C.D.# (#co-corresponding author)
Oral
administration of p-hydroxycinnamic acid attenuates atopic dermatitis by downregulating
Th1 and Th2 cytokine production and keratinocyte activation.
PLoS One. 2016 Mar 9;11(3):e0150952.
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Lee H.S., Choi E.J., Choi H., Lee K.S., Kim H.R., Na B.R., Kwon M.S., Jeong G.S., Choi H.G., Choi E.Y.#,
Jun C.D.# (#co-corresponding author)
Oral administration
of 4-hydroxy-3-methoxycinnamaldehyde attenuates atopic dermatitis by
inhibiting T cell and keratinocyte activation.
PLOS ONE. 2015 Dec 10; 10(12):e0144521.
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Lee SH, Kim DY, Jing F,
Kim H, Yun CO, Han DJ, Choi EY. (corresponding
author)
Del-1 overexpression potentiates
lung cancer cell proliferation and invasion.
Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):92-8.
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Choi E.Y*#.,
Lim J.H*., Neuwirth A., Economopoulou M., Chatzigeorgiou A., Chung K.J.,
Bittner S., Lee S.H., Neuwirth A., Langer H., Samus M., Kim H., Cho G.S.,
Ziemssen T., Bdeir K., Chavakis E., Koh J.Y., Boon L., Bornstein S.R., Meuth
S.G., Hajishengallis G., Chavakis T. (#corresponding
author; * co-first author)
Developmental
endothelial locus-1 (Del-1) is a homeostatic factor in the central nervous
system limiting neuroinflammation and demyelination.
Mol Psychiatry. 2015
Jul;20(7):880-8.
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Kang Y.Y., Kim D.Y., Lee S.H., Choi E.Y. (corresponding author)
Deficiency of developmental endothelial locus-1 (Del-1)
aggravates bleomycin-induced pulmonary fibrosis in mice.
Biochem Biophys Res Commun. 2014 Mar 7;445(2):369-74.
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Lee S.H., Kim D.Y., Kang Y.Y., Kim H., Jang J., Lee M.N.,
Oh G.T., Kang S.W., Choi E.Y. (corresponding author)
Developmental endothelial locus-1 inhibits MIF
production through suppression of NF-kB in macrophages.
Int J Mol
Med.
2014 Apr;33(4):919-24.
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Mitroulis I., Kang Y.Y.,
Gahmberg C.G., Siegert G., Hajishengallis G., Chavakis T., Choi
E.Y. (corresponding author)
Developmental endothelial
locus-1 attenuates complement-dependent phagocytosis through inhibition of
Mac-1-integrin.
Thromb Haemost. 2014 May 5;111(5):1004-6.
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Kim H., Lee S.H., Lee M.N.,
Oh G.T., Choi K.C., Choi E.Y. (corresponding author)
p53 regulates the
transcription of the anti-inflammatory molecule developmental endothelial
locus-1 (Del-1).
Oncotarget. 2013 Nov;4(11):1976-85.
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발표논문 (2010 연구실 이전, selected)
Langer H.F.*, Choi E.Y.*, Zhou H, Schleicher
R, Chung K.J., Tang Z., Göbel K., Bdeir K., Chatzigeorgiou A., Wong C.,
Bhatia S., Kruhlak M.J., Rose J.W., Burns J.B., Hill K.E., Qu H., Zhang Y.,
Lehrmann E., Becker K.G., Wang Y., Simon D.I., Nieswandt B., Lambris J.D., Li
X., Meuth S.G., Kubes P., Chavakis
T. (* co-first author)
Platelets contribute to the
pathogenesis of experimental autoimmune encephalomyelitis.
Circ Res. 110(9):1202-10, 2012
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Eskan M.A., Jotwani R.,
Abe T., Jindrich C., Lim J.H., Liang S., Ciero
P.A., Krauss J.L., Li F., Rauner M., Hofbauer L.C., Choi E.Y.,
Chung K.J., Hashim A., Curtis M.A., Chavakis T.,
Hajishengallis G.
The
leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone
loss.
Nat Immunol. 13(5):465-73, 2012.
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Choi E.Y., Chavakis E., Czabanka M.A., Langer H.F., Fraemohs
L., Economopoulou M., Kundu R.K., Orlandi A., Zheng Y.Y., Prieto D.A.,
Ballantyne C.M., Constant S.L., Aird W.C., Papayannopoulou T., Gahmberg C.G.,
Udey M.C., Vajkoczy P., Quertermous T., Dimmeler S., Weber C., Chavakis T. (first author)
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits
inflammatory cell recruitment.
Science.
322(5904): 1009-1144, 2008.
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Choi E.Y., Orlova V.V., Fagerholm
S.C., Nurmi S.M, Zhang L., Ballantyne C.M., Gahmberg
C.G., Chavakis T.
(first author)
Regulation of LFA-1-dependent inflammatory cell
recruitment by Cbl-b and 14-3-3 proteins.
Blood. 111(7):3607-14, 2008.
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Choi, E.Y., Kim, E.C., Oh, H.M., Kim,
S., Lee, H.J., Cho, E.Y., Yoon, K.H., Kim, E.A., Han, W.C., Choi, S.C.,
Hwang, J.Y., Park, C., Oh, B.S., Kim, Y., Kim, K.C., Park, K.I., Chung, H.T.,
Jun, C.D. (first author)
Iron chelator triggers inflammatory signals in human
intestinal epithelial cells:
involvement of p38 and extracellular signal-regulated kinase signaling
pathways.
J Immunol.
172(11):7069-77, 2004.
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