아산융합의학원

연구실 소개

뼈면역세포생물학연구실 (의생명과학교실)

울산의대 의생명과학교실 소속 뼈면역세포생물학연구실 (Chang's Osteoimmunology Lab (CLOI))로 현재 기초의과학 연구센터 (MRC), 한국연구재단, 보건복지부와 아산생명과학연구소 등의 연구비를 지원받아 많은 연구들을 진행하고 있습니다.

본 연구실은 박사급 연구원과 그 외 연구원들이 주축이 되어 염증매개 관련 질환들 (염증성 뼈질환, 석회화 관련 대사질환, 뼈전이암 포함)의 병인 연구를 중심으로 골수줄기세포 분화와 활성조절, 대식세포 상호작용과 활성, 뼈전이암에 의한 뼈미세환경 조절 연구를 바탕으로 관련질환의 치료 타깃 발굴 연구를 목표로 합니다.

특히 2018년 선정된 MRC 줄기세포 면역제어 연구센터에 참여하여 줄기세포와 면역활성 조절 상호작용 기전 연구를 바탕으로 면역제어 타깃 발굴을 통해 난치성 면역질환의 표적 세포치료제 개발 연구에 참여하고 있습니다. 이를 위해 세포 수준, 질환 동물모델 연구와 임상적 유용성 검증 연구를 수행 중에 있습니다.

주요 연구 내용은 다음과 같습니다.

뼈질환 동물 모델을 이용한 질환의 병태 분석과 세포수준 작용 기전 연구
염증성 심혈관 질환 동물모델을 이용한 타깃 물질의 기능 분석과 기전 연구
뼈로의 암전이 동물 모델을 이용한 뼈미세환경 조절 타깃 기능 분석과 세포기전 연구
염증성 대사질환 관련 병인인자 연구
줄기세포 면역활성제어 타깃 발굴을 통한 난치성 면역질환 표적 세포치료제 개발 연구

주요 논문

1. Osteoclast-secreted SLIT3 coordinates bone resorption and formation. J. Clin. Invest., 2018 March.

2. Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulinlike Growth Factor-1 Signaling in Valvular Interstitial Cells. Circulation. 2017 Feb.

3. Interleukin-32 Gamma Stimulates Bone Formation by Increasing miR-29a in Osteoblastic Cells and Prevents the Development of Osteoporosis. Sci Rep. 2017 Jan.

4. Upregulation of brain-derived neurotrophic factor in advanced gastric cancer contributes to bone metastatic osteolysis by inducing long pentraxin 3. Oncotarget. 2016 Jul.

5. Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes. Sci Rep. 2016 Jan.

6. High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation. Arthritis Res Ther. 2015 Dec.

7. Pentraxin-3 Silencing Suppresses Gastric Cancer-related Inflammation by Inhibiting Chemotactic Migration of Macrophages. Anticancer Res. 2015 May.

8. Atrazine induces endoplasmic reticulum stress-mediated apoptosis of T lymphocytes via the caspase-8-dependent pathway. Environ Toxicol. 2016 Aug.

9. Beclin-1 Is Required for RANKL-Induced Osteoclast Differentiation. J Cell Physiol. 2014 Dec.

10. PTX3 Stimulates Osteoclastogenesis by Increasing Osteoblast RANKL Production. J Cell Physiol. 2014 Nov.

11. Interleukin-1β promotes the LC3-mediated secretory function of osteoclast precursors by stimulating the Ca²⁺-dependent activation of ERK. Int J Biochem Cell Biol. 2014 Sep.

12. IL-34 is associated with obesity, chronic inflammation, and insulin resistance. J Clin Endocrinol Metab. 2014 Jul.

13. Elevated Pentraxin 3 in bone metastatic breast cancer is correlated with osteolytic function. Oncotarget. 2014 Jan.

14. Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation. Sci Transl Med. 2012 Jun.

15. Microtubule-associated protein light chain 3 regulates Cdc42-dependent actin ring formation in osteoclast. Int J Biochem Cell Biol. 2012 Jun.

16. Increased phosphorylation of dynaminrelated protein 1 and mitochondrial fission in okadaic acid-treated neurons. Brain Res. 2012 May.

17. Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis. Arthritis Res Ther. 2012 Jan.

18. AWP1 binds to tumor necrosis factor receptorassociated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. Int J Biochem Cell Biol. 2011 Nov.

19. Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation. Biochem Biophys Res Commun. 2009 Nov.

20. The JNK-dependent CamK pathway restrains the reversion of committed cells during osteoclast differentiation. J Cell Sci. 2008 Aug.

21. Brain-type creatine kinase plays a critical role in osteoclast-mediated bone resorption. Nat Med. 2008 Sep.

22. The role of nerve growth factor in apoptosis induced by hyperosmolar stress. J Cell Physiol. 2008 Jul.

23. The Ubiquitin-mediated Degradation of Jak1 Modulates Osteoclastogenesis by Limiting Interferon-b-induced Inhibitory Signaling. Blood 2008 Jan.

24. Hyaluronan inhibits osteoclast differentiation via Toll-like receptor 4. J Cell Sci. 2007 Jan.

25. Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. EMBO J. 2006 Dec.

26. Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of mitochondria-dependent caspase activation. Int J Biochem Cell Biol. 2006.

27. Low proliferation and high apoptosis of osteoblastic cells on hydrophobic surface are associated with defective Ras signaling. Exp Cell Res. 2005 Feb.

28. Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing NF-kappaB activation. Mol Cells. 2004 Oct.

29. Elucidation of CPX-1 involvement in RANKL-induced osteoclastogenesis by a proteomics approach. FEBS Lett. 2004 Apr.

30. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc Natl Acad Sci U S A. 2002 Aug.

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